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首页> 外文OA文献 >Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and ghrelin concentrations in healthy subjects.
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Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and ghrelin concentrations in healthy subjects.

机译：1和3g肉桂对健康受试者的胃排空，饱腹感和餐后血糖，胰岛素，葡萄糖依赖性促胰岛素多肽，胰高血糖素样肽-1和生长素释放肽浓度的影响。

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BACKGROUND: A previous study of healthy subjects showed that intake of 6 g cinnamon with rice pudding reduced postprandial blood glucose and the gastric emptying rate (GER) without affecting satiety. OBJECTIVE: The objective was to study the effect of 1 and 3 g cinnamon on GER, postprandial blood glucose, plasma concentrations of insulin and incretin hormones [glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)], the ghrelin response, and satiety in healthy subjects. DESIGN: GER was measured by using real-time ultrasonography after ingestion of rice pudding with and without 1 or 3 g cinnamon. Fifteen healthy subjects were assessed in a crossover trial. RESULTS: The addition of 1 or 3 g cinnamon had no significant effect on GER, satiety, glucose, GIP, or the ghrelin response. The insulin response at 60 min and the area under the curve (AUC) at 120 min were significantly lower after ingestion of rice pudding with 3 g cinnamon (P = 0.05 and P = 0.036, respectively, after Bonferroni correction). The change in GLP-1 response (DeltaAUC) and the change in the maximum concentration (DeltaC(max)) were both significantly higher after ingestion of rice pudding with 3 g cinnamon (P = 0.0082 and P = 0.0138, respectively, after Bonferroni correction). CONCLUSIONS: Ingestion of 3 g cinnamon reduced postprandial serum insulin and increased GLP-1 concentrations without significantly affecting blood glucose, GIP, the ghrelin concentration, satiety, or GER in healthy subjects. The results indicate a relation between the amount of cinnamon consumed and the decrease in insulin concentration.
机译：背景：先前对健康受试者的研究表明，大米布丁摄入6克肉桂可降低餐后血糖和胃排空率（GER），而不会影响饱腹感。目的：研究1和3克肉桂粉对GER，餐后血糖，血浆胰岛素和肠降血糖素激素[葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）的影响。 ]，ghrelin反应和健康受试者的饱腹感。设计：摄入或不加入1或3克肉桂的大米布丁后，通过实时超声检查来测量GER。在一项交叉试验中评估了15名健康受试者。结果：添加1或3 g肉桂对GER，饱食感，葡萄糖，GIP或生长激素释放肽反应无明显影响。服用3 g肉桂的大米布丁后，60分钟时的胰岛素反应和120分钟时的曲线下面积（AUC）显着降低（Bonferroni校正后分别为P = 0.05和P = 0.036）。摄取3 g肉桂的布丁后，Bonferroni校正后，GLP-1反应的变化（DeltaAUC）和最大浓度的变化（DeltaC（max）均显着较高（分别为P = 0.0082和P = 0.0138） ）。结论：摄入3 g肉桂可减少健康受试者的餐后血清胰岛素并增加GLP-1浓度，而不会显着影响血糖，GIP，ghrelin浓度，饱腹感或GER。结果表明肉桂消耗量与胰岛素浓度降低之间的关系。

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